2013

Presidio Pharmaceuticals Announces a High Rate of Virologic Response in an Ongoing Phase 2 Hepatitis C Trial of a New All-Oral Combination of Presidio’s PPI-668 with Boehringer Ingelheim’s Faldaprevir and Deleobuvir

San Francisco, CA – November 2, 2013 – Presidio Pharmaceuticals, Inc. announced today positive preliminary results from an ongoing Phase 2 clinical trial of an investigational, interferon-free, all-oral combination treatment for patients with chronic hepatitis C virus (HCV) infection. The collaborative trial is evaluating Presidio’s pan- genotypic HCV NS5A inhibitor (PPI-668) in combination with Boehringer Ingelheim’s HCV protease inhibitor faldaprevir (BI 201335) and non-nucleoside HCV polymerase inhibitor deleobuvir (BI 207127), with and without ribavirin (RBV). (PDF)

Investigational Interferon-free Regimen Demonstrates Undetectable Hepatitis C Virus in All Patients Reaching End of Treatment in Ongoing Phase 2 Trial

Ridgefield, CT – October 8, 2013 – Boehringer Ingelheim Pharmaceuticals, Inc. today announced that interim data from its Phase 2 hepatitis C (HCV) clinical collaboration (NCT01859962) with Presidio Pharmaceuticals have been accepted as a late breaker poster presentation at the 64th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), also known as The Liver Meeting®, taking place November 1-5 in Washington, D.C. The poster presentation will be on Monday, November 4.

This ongoing study evaluates a 12-week, all-oral regimen of Boehringer Ingelheim’s investigational compounds, the protease inhibitor, faldaprevir (BI 201335), and non-nucleoside NS5B polymerase inhibitor, deleobuvir (BI 207127), in combination with Presidio’s investigational pan-genotypic NS5A inhibitor, PPI-668, with and without ribavirin. The study is fully enrolled (36 patients) and to date, 97 percent of patients (28/29) have achieved undetectable levels of virus by week 4 on treatment, also known as rapid virologic response (RVR). Additionally, 100 percent of patients who have completed treatment (13/13) achieved non-detectable levels of virus at the end of treatment. (link)

Boehringer Ingelheim Expands Investigation of Interferon-free Hepatitis C Treatment Regimens to Reach More Patient Types through Presidio Pharmaceuticals Clinical Collaboration

Ridgefield, CT, September 10, 2013 – Boehringer Ingelheim Pharmaceuticals, Inc. today announced the completion of patient enrollment for a Phase 2a clinical trial (NCT01859962) investigating a new interferon-free, all-oral, direct-acting antiviral (DAA) combination treatment for patients with genotype-1a chronic hepatitis C virus (HCV) infection. This trial is conducted in collaboration with Presidio Pharmaceuticals, Inc. and evaluates Boehringer Ingelheim’s investigational compounds, the protease inhibitor faldaprevir (BI 201335) and non-nucleoside NS5B polymerase inhibitor, deleobuvir (BI 207127), in combination with Presidio’s investigational pan-genotypic NS5A inhibitor, PPI-668, with and without ribavirin. (link)

Presidio Pharmaceuticals Announces Collaboration with
Boehringer Ingelheim

San Francisco, CA – March 12, 2013 – Presidio Pharmaceuticals, Inc. announced today a non-exclusive collaboration with Boehringer Ingelheim for a Phase IIa clinical trial of an interferon-free, all-oral, direct-acting antiviral (DAA) combination treatment for patients with chronic hepatitis C virus (HCV) infection.The collaborative trial will evaluate Presidio’s pan-genotypic HCV NS5A inhibitor (PPI-668) in combination with Boehringer Ingelheim’s HCV protease inhibitor faldaprevir (BI201335) and its non-nucleoside HCV polymerase inhibitor (BI207127), with or without ribavirin. PDF

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